The range of hemoglobin A(2) in hemoglobin E heterozygotes as determined by capillary electrophoresis.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 19864231.
- Also identified by DOI 10.1309/AJCPP50JIXXZVLSS.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Capillary electrophoresis (CE) is capable of distinguishing hemoglobin E (HbE) from hemoglobin A(2) (HbA(2)), thus permitting quantification of HbA(2) in patients with HbE. In this study, routine samples submitted for evaluation of hemoglobinopathy that demonstrated HbE were studied by high-pressure liquid chromatography and CE. The data for 52 samples from adult HbE heterozygotes were compared with those for a control group consisting of 209 patients. The mean HbA(2) of patients with HbE trait was 3.4% (SD, 0.4%), which was significantly higher (P < .001) than the 2.6% (SD, 0.4%) for the control group. Seven samples from adults homozygous for HbE were also evaluated. The mean HbA(2) of HbE homozygotes was 4.4%, which was significantly greater (P < .001) than the HbA(2) values for the HbE heterozygotes. Data from these cases provide an estimate of the range of HbA(2) in patients with HbE when evaluated by CE.
Medical subject headings
- Electrophoresis, Capillary
- Hemoglobin A2
- Hemoglobin E