Potential utility of PPARalpha activation in the prevention of ischemic and drug-induced acute renal damage.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 19876055.
- Also identified by DOI 10.1038/ki.2009.229.
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Abstract
Acute renal failure induced by renal ischemia or drugs continues to be a relevant clinical problem. Li et al. have demonstrated that proximal tubule-restricted peroxisome proliferator-activated receptor-alpha (PPARalpha) expression in transgenic mice reduced cisplatin- and ischemia/reperfusion-induced acute renal injury. Their article suggests a role for the maintenance of free fatty acid oxidation in the proximal tubule as a mechanism of nephroprotection, as well as a potential clinical utility of PPARalpha activators in the prevention of acute renal failure.
Medical subject headings
- Acute Kidney Injury
- PPAR alpha
- Reperfusion Injury