Quiet gene circuit more fragile than its noisy peer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19879833.
- Also identified by DOI 10.1016/j.cell.2009.10.005.
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Abstract
Why is a particular architecture for a pathway chosen over seemingly equivalent alternatives? Cağatay et al. (2009) use a synthetic biology approach to show that fluctuations--or noise--in protein levels may play a key role in determining which network design is selected during evolution.
Medical subject headings
- Bacillus subtilis
- Gene Regulatory Networks
- Models, Biological