PI3 kinase signals BCR-dependent mature B cell survival.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19879843.
- Also identified by DOI 10.1016/j.cell.2009.08.041 and PMC identifier 2787092.
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Abstract
Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.
Medical subject headings
- B-Lymphocytes
- Cell Survival
- Phosphatidylinositol 3-Kinases
- Receptors, Antigen, B-Cell