Supramolecular protein cage composite MR contrast agents with extremely efficient relaxivity properties.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19888720.
- Also identified by DOI 10.1021/nl902884p and PMC identifier 3625947.
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Abstract
A DTPA-Gd containing polymer was grown in the interior of a heat shock protein cage resulting in T(1) particle relaxivities of 4200 mM(-1) sec(-1) for the 12 nm particle. Relaxivity parameters were determined, and this analysis suggests that the rotational correlation time has been optimized while the water exchange lifetime is longer than optimal. This synthetic approach holds much promise for the development of next generation contrast agents and this report will aid in their design.
Medical subject headings
- Contrast Media
- Drug Carriers
- Gadolinium DTPA
- Heat-Shock Proteins
- Image Enhancement
- Magnetic Resonance Imaging