Preview. Inhibition of Tgf-beta signaling improves mouse fibroblast reprogramming.
editorial · Level V
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- Record sourced from PubMed, PMID 19896434.
- Also identified by DOI 10.1016/j.stem.2009.10.007.
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Abstract
Circumventing genomic modification in induced pluripotent stem cell (iPSC) derivation is a clear requirement to realize safe clinical applications. In this issue of Cell Stem Cell, Ichida et al., (2009) describe a small molecule capable of replacing Sox2, offering insight into the reprogramming process.