Two frameshift mutations in the cystic fibrosis gene.
basic_science · Level V
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- Record sourced from PubMed, PMID 1990834.
- Also identified by PMC identifier 1683026.
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Abstract
Cystic fibrosis (CF) is a recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. We have identified in exon 7 two frameshift mutations, one caused by a two-nucleotide insertion and the other caused by a one-nucleotide deletion; these mutations--CF1154insTC and CF1213delT, respectively, are predicted to shift the reading frame of the protein and to introduce UAA(ochre) termination codons at residues 369 and 368.
Medical subject headings
- Cystic Fibrosis
- Frameshift Mutation