Saturating the region of the polycystic kidney disease gene with NotI linking clones.
basic_science · Level V
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- Record sourced from PubMed, PMID 1990840.
- Also identified by PMC identifier 1683004.
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Abstract
A NotI-linking library was constructed from a radiation hybrid containing fragments of human chromosome 16. The clones were mapped on a panel of somatic cell hybrids, and 10 different NotI site-containing clones were localized close to and between genetic markers flanking the PKD1 locus. With pulsed-field gel analysis the clones were shown to be distributed over four adjacent ClaI fragments covering 1,200 kb.
Medical subject headings
- Genetic Linkage
- Polycystic Kidney Diseases