Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion.
Level V
Where this comes from
- Record sourced from PubMed, PMID 19910947.
- Also identified by DOI 10.1038/ki.2009.352.
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Abstract
Advanced oxidation protein products (AOPPs), a protein biomarker of increased oxidative stress, are elevated in uremic patients. Zhou et al. demonstrate that chronic administration of AOPPs induces podocyte apoptosis and proteinuria in normal rats via a cascade of signaling events. This study for the first time establishes a causative link between oxidative stress and podocyte depletion and could have broad implications in our understanding of the pathogenic mechanism of proteinuria.
Medical subject headings
- Oxidative Stress
- Podocytes
- Proteins