Long-term evolution and determinants of renal function in HIV-infected patients who began receiving combination antiretroviral therapy in 1997-1999, ANRS CO8 APROCO-COPILOTE.

Leport, Catherine; Bouteloup, Vincent; Rossert, Jérôme; Garré, Michel; Iordache, Laura; Dellamonica, Pierre; Herson, Serge; Raffi, François et al. · Clin Infect Dis · 2009

prospective_cohort · Level II

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Abstract

Among 1121 patients (90% Caucasian) infected by the human immunodeficiency virus (HIV), the glomerular filtration rate increased (+0.72 mL/min/1.73 m(2)/month) from treatment initiation to month 16 (the rate increase was lower among men and those with low body mass index, AIDS, or receipt of indinavir), then remained stable up to 7 years. Kidney function should be monitored in patients previously exposed to indinavir.

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