Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid.

Lechowicz, Maryjo; Dittmer, Dirk P; Lee, Jeannette Y; Krown, Susan E; Wachsman, William; Aboulafia, David; Dezube, Bruce J; Ratner, Lee et al. · Clin Infect Dis · 2009

case_series · Level IV

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Abstract

The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.

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