Putting two heads together to unwind DNA.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19914158.
- Also identified by DOI 10.1016/j.cell.2009.10.037.
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Abstract
The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.
Medical subject headings
- DNA
- DNA Replication
- Saccharomyces cerevisiae