Transformation locked in a loop.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19914159.
- Also identified by DOI 10.1016/j.cell.2009.10.035.
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Abstract
During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.
Medical subject headings
- Cell Transformation, Neoplastic
- Feedback, Physiological
- Inflammation
- Interleukin-6