Finale: the last minutes of Smads.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19914161.
- Also identified by DOI 10.1016/j.cell.2009.10.038.
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Abstract
TGF-beta ligands induce phosphorylation of receptor-activated Smads at both the C-terminal tail and the linker region. Two papers from Massagué and colleagues (Alarcón et al., 2009; Gao et al., 2009) reveal a dual role for this linker phosphorylation, which is required for activation of Smads and for their degradation.
Medical subject headings
- Smad Proteins
- Transcriptional Activation