Polarity is destiny.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19914162.
- Also identified by DOI 10.1016/j.cell.2009.10.040 and PMC identifier 2900917.
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Abstract
The GTPase Cdc42 specifies polarity in various biological processes. Kesavan et al. (2009) now demonstrate that Cdc42 also regulates epithelial cell polarity in the developing mouse pancreas, where it is required for tubule formation and maintenance. Furthermore, the polarization of epithelial tissue influences the differentiation of pancreatic progenitor cells, linking cell polarity to cell specification.
Medical subject headings
- Cell Polarity
- Organogenesis
- Pancreas