Phenytoin toxicity due to interaction with clobazam.
case_series · Level IV
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- Record sourced from PubMed, PMID 1992382.
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Abstract
The benzodiazepine antiepileptic drug clobazam can be added to existing AED treatment, usually without clinical toxicity. We report 3 patients in whom the addition of clobazam led within several weeks to clinically obvious phenytoin (PHT) intoxication in patients who had been taking maximum tolerable PHT doses. Symptoms and high PHT levels resolved with lowering the PHT dose. Clobazam and norclobazam levels were not elevated. This interaction is probably related to interference with hepatic degradation of PHT. Clinicians should be aware of possible PHT intoxication in patients starting clobazam.
Medical subject headings
- Anti-Anxiety Agents
- Benzodiazepines
- Benzodiazepinones
- Phenytoin