Human genetics illuminates the paths to metabolic disease.
review · Level V
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- Record sourced from PubMed, PMID 19924209.
- Also identified by DOI 10.1038/nature08532.
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Abstract
Metabolic diseases represent a growing threat to world-wide public health. In general, these disorders result from the interaction of heritable factors with environmental influences. Here, I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and explore the extent to which human molecular genetic research has illuminated our understanding of their underlying pathophysiological mechanisms.
Medical subject headings
- Diabetes Mellitus, Type 2
- Obesity