TrkB signalling pathways in LTP and learning.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19927149.
- Also identified by DOI 10.1038/nrn2738.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Understanding the mechanisms that underlie learning is one of the most fascinating and central aims of neurobiological research. Hippocampal long-term potentiation (LTP) is widely regarded as a prime candidate for the cellular mechanism of learning. The receptor tyrosine kinase TrkB (also known as NTRK2), known primarily for its function during PNS and CNS development, has emerged in recent years as a potent regulator of hippocampal LTP. Here I describe efforts to understand the signalling pathways and molecular mechanisms that underlie the involvement of TrkB in LTP and learning.
Medical subject headings
- Learning
- Long-Term Potentiation
- Receptor, trkB
- Signal Transduction