Synthesis and thermally reversible assembly of DNA-gold nanoparticle cluster conjugates.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19928782.
- Also identified by DOI 10.1021/nl9030709.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We describe the facile synthesis of stable gold nanoparticle clusters densely functionalized with DNA (DNA-AuNP clusters) using dithiothreitol and monothiol DNA and their thermally reversible assembly properties. The size of the clusters exhibits a very narrow distribution and can be easily controlled by adjusting the stoichiometry of dithiothreitol and DNA, leading to a variety of colors due to the surface plasmon resonance of the AuNP clusters. Importantly, the DNA-AuNP clusters exhibit highly cooperative melting properties with distinctive and diverse color changes depending on their size. The selective and sensitive colorimetric detection of target sequences was demonstrated based upon the unique properties of the DNA-AuNP clusters.
Medical subject headings
- Crystallization
- DNA
- Gold
- Nanostructures
- Nanotechnology