Targeting histone demethylases in cancer therapy.
Level V
Where this comes from
- Record sourced from PubMed, PMID 19934292.
- Also identified by DOI 10.1158/1078-0432.CCR-09-2399 and PMC identifier 2803074.
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Abstract
A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition to the armamentarium of epigenetic agents.
Medical subject headings
- Antineoplastic Agents
- Histone Demethylases
- Neoplasms