Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 19936608.
- Also identified by DOI 10.1007/s00701-009-0555-3.
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Abstract
Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T-cell phenotype and a Ki67 proliferation index of only 1%. Contrary to the prevailing view in the literature, the patient's clinical condition deteriorated following high-dose intravenous methotrexate and improved after a short course of whole-brain radiotherapy.
Medical subject headings
- Antimetabolites, Antineoplastic
- Cerebellar Neoplasms
- Cranial Irradiation
- Lymphoma, T-Cell
- Methotrexate