Flare-up of hand osteoarthritis caused by zoledronic acid infusion.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 19936866.
- Also identified by DOI 10.1007/s00198-009-1123-7.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Zoledronic acid is effective for osteoporosis at a single annual intravenous dose. It usually causes few adverse effects; the most common are related to acute phase reactions. We reported the case of a 64-year-old woman who presented flare-up of hand osteoarthritis after zoledronic acid infusions. Despite the fact that arthralgia is a common side effect of intravenous bisphosphonates, development of inflammatory signs in osteoarthritic joints is a rare event. We hypothesized that this side effect is caused by a release of cytokines secondary to activation of gamma-delta T lymphocytes.
Medical subject headings
- Bone Density Conservation Agents
- Diphosphonates
- Hand Joints
- Imidazoles
- Osteoarthritis