X chromosome inactivation: when dosage counts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19945374.
- Also identified by DOI 10.1016/j.cell.2009.11.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
How do mammals count their X chromosomes and keep only one X active per cell? In this issue, Jonkers et al. (2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active.
Medical subject headings
- X Chromosome
- X Chromosome Inactivation