How iron controls iron.
Where this comes from
- Record sourced from PubMed, PMID 19945401.
- Also identified by DOI 10.1016/j.cmet.2009.11.005.
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Abstract
Cells regulate iron homeostasis by posttranscriptional regulation of proteins responsible for iron uptake and storage. This requires RNA-binding activity of iron-regulatory proteins, IRP1 and IRP2. Two studies recently published in Science by Vashisht et al. (2009) and Salahudeen et al. (2009) reveal how cells adjust IRP2 activity.