Vitamin D: a new hope for chronic kidney disease?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19946310.
- Also identified by DOI 10.1038/ki.2009.390.
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Abstract
Vitamin D analogs may slow the progression of chronic kidney disease. Tan et al. report that paricalcitol has additive effects with an angiotensin-converting enzyme inhibitor (ACEI) in suppressing extracellular matrix expression, interstitial inflammation, and myofibroblast activation in obstructive nephropathy. Paricalcitol inhibited renin transcription, countering the compensatory ACEI-induced rise in renin, thus achieving a more complete blockade of the renin-angiotensin system (RAS). Vitamin D analogs may enhance the renoprotective effects of RAS inhibitors.
Medical subject headings
- Renal Insufficiency, Chronic
- Vitamin D