Degradation of human cartilage by synovial fluid but not cytokines in vitro.
basic_science · Level V
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- Record sourced from PubMed, PMID 1994871.
- Also identified by PMC identifier 1004328.
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Abstract
Synovial fluids from patients with rheumatoid arthritis and from patients with osteoarthritis degraded the matrix of living, but not killed, normal human cartilage as judged by loss of glycosaminoglycans. Normal human serum did not degrade living cartilage and neither, unexpectedly, did recombinant human cytokines.
Medical subject headings
- Arthritis
- Cartilage, Articular
- Cytokines
- Synovial Fluid