Transient renal insufficiency following dipyrone overdose.

Abstract

To describe the incidence of acute renal insufficiency after dipyrone overdose in children. The medical records of all patients < or =18 years of age during a 3-year period presenting at Assaf Harofeh Medical Center due to toxic exposure were retrospectively reviewed. Patients suffering from dipyrone overdose were compared with all the other patients. 235 cases were included in the final analysis. Of these, 26 (11%) patients were exposed to dipyrone (median age 15 years). Three of the 26 patients (12%) had transient non-oliguric renal insufficiency. One other patient who did not receive dipyrone also developed transient renal insufficiency. Dipyrone overdose is frequent and may cause acute non-oliguric renal insufficiency. Renal function should be monitored in such patients.