An algorithm for managing warfarin resistance.
review · Level V
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- Record sourced from PubMed, PMID 19952297.
- Also identified by DOI 10.3949/ccjm.76a.09062.
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Abstract
Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.