Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 19958312.
- Also identified by DOI 10.1111/j.1398-9995.2009.02285.x.
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Abstract
A functional defect of T regulatory cells (Treg) has been proposed as pathogenic mechanism of allergic reaction. Polysensitization is a common feature of allergic patients. It was to investigate the possible role of Treg-Th1 cytokines, in the development of new sensitizations in childhood. Forty monosensitized (MS) children with allergic rhinitis were evaluated and followed-up for 2 years. New sensitizations were investigated. IL-10 and IFN-gamma were evaluated in in vitro experiments. Children remaining MS showed significant higher production of both IL-10 and IFN-gamma. This preliminary study provided evidence that IL-10 and IFN-gamma production could be defective in allergic children prone to develop polysensitization.
Medical subject headings
- Hypersensitivity
- Interferon-gamma
- Interleukin-10