Protein nanocapsule weaved with enzymatically degradable polymeric network.
basic_science · Level V
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- Record sourced from PubMed, PMID 19995089.
- Also identified by DOI 10.1021/nl902935b.
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Abstract
Target proteins can be functionally encapsulated using a cocoon-like polymeric nanocapsule formed by interfacial polymerization. The nanocapsule is cross-linked by peptides that can be proteolyzed by proteases upon which the protein cargo is released. The protease-mediated degradation process can be controlled in a spatiotemporal fashion through modification of the peptide cross-linker with photolabile moieties. We demonstrate the utility of this approach through the cytoplasmic delivery of the apoptosis inducing caspase-3 to cancer cells.
Medical subject headings
- Caspase 3
- Nanocapsules
- Polymers