A syndrome characterized by nodular eosinophilic infiltration of the skin and immunoglobulin isotype imbalance.
case_report · Level V
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Abstract
A 9-year-old boy had recurrent acute, plaquelike, nodular infiltrations with overlying vesicles and bullae of the face and right hand. Histologically, the lesions consisted of a perivascular and periadnexal lymphohistiocytic infiltrate with many eosinophils. The lesions responded to dapsone therapy. Laboratory studies revealed blood eosinophilia, hyperimmunoglobulinemias E and G4, and hypoimmunoglobulinemias M and G1-3, which normalized after treatment. The patient's immune deviation is consistent with a transient imbalance of lymphokine production in helper T cells.
Medical subject headings
- Dysgammaglobulinemia
- Eosinophilia
- Hypergammaglobulinemia
- Skin Diseases