ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19996286.
- Also identified by DOI 10.1158/0008-5472.CAN-09-2641 and PMC identifier 3237114.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The BRCA1-interacted transcriptional repressor ZBRK1 has been associated with antiangiogenesis, but direct evidence of a tumor suppressor role has been lacking. In this study, we provide evidence of such a role in cervical carcinoma. ZBRK1 levels in cervical tumor cells were significantly lower than in normal cervical epithelial cells. In HeLa cervical cancer cells, enforced expression inhibited malignant growth, invasion, and metastasis in a variety of in vitro and in vivo assays. Expression of the metalloproteinase MMP9, which is known to be an important driver of invasion and metastasis, was found to be inversely correlated with ZBRK1 in tumor tissues and a target for repression in tumor cells. Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression.
Medical subject headings
- Gene Expression Regulation, Neoplastic
- Matrix Metalloproteinase 9
- Neoplasm Invasiveness
- Repressor Proteins
- Uterine Cervical Neoplasms