Adult-type granulosa cell tumors and FOXL2 mutation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19996294.
- Also identified by DOI 10.1158/0008-5472.CAN-09-2669.
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Abstract
Little is known about the pathogenesis of ovarian granulosa cell tumors. Recently, we reported the identification of a somatic FOXL2 402C-->G mutation that is present in virtually all adult-type granulosa cell tumors, but not in a wide range of other tumor types. This finding has important implications for the diagnosis and classification of ovarian sex cord-stromal tumors, provides insight into the pathogenesis of adult-type granulosa cell tumors, and opens possibilities for the development of targeted therapies.
Medical subject headings
- Forkhead Transcription Factors
- Granulosa Cell Tumor
- Ovarian Neoplasms