Hyperandrogenaemia in adolescent girls: origins of abnormal gonadotropin-releasing hormone secretion.
Where this comes from
- Record sourced from PubMed, PMID 20002394.
- Also identified by DOI 10.1111/j.1471-0528.2009.02383.x and PMC identifier 2994606.
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Abstract
Polycystic ovarian syndrome is a common disorder characterized by ovulatory dysfunction and hyperandrogenemia (HA). Its origins begin peripubertally, as adolescent HA commonly leads to adult HA and decreased fertility. HA reduces inhibition of gonadotropin releasing hormone pulse frequency by progesterone, causing rapid LH pulse secretion and further increasing ovarian androgen production. Obese girls are at risk for HA and develop increased LH pulse frequency with elevated mean LH by late puberty. Many girls with HA do not exhibit normal LH pulse sensitivity to progesterone inhibition. Thus, HA may adversely affect LH pulse regulation during pubertal maturation leading to persistent HA.
Medical subject headings
- Gonadotropin-Releasing Hormone
- Hyperandrogenism
- Menstrual Cycle
- Polycystic Ovary Syndrome
- Puberty