Low body adiposity and high leptinemia in breast-fed infants born small-for-gestational-age.

Ibáñez, Lourdes; Sebastiani, Giorgia; Diaz, Marta; Gómez-Roig, Maria Dolores; Lopez-Bermejo, Abel; de Zegher, Francis · J Pediatr · 2010

case_control · Level III

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Abstract

Breast-fed infants born small-for-gestational-age (SGA) (n = 28) were found to develop lower adiposity across early infancy, when compared with appropriate-for-gestational age infants (n = 46). The SGA infants were also found to have 2-fold higher (P < .001) levels of circulating leptin at 4 months. This paradoxical hyperleptinemia in early infancy may contribute to a program that produces a process from fetal underweight to adult overweight.

Medical subject headings