Potato virus X as a novel platform for potential biomedical applications.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20017489.
- Also identified by DOI 10.1021/nl9035753 and PMC identifier 2958517.
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Abstract
We demonstrate that nanoparticles formed from the rod-shaped plant virus Potato virus X (PVX) can serve as a novel platform for biomedical applications. Bioconjugation protocols including amine modification and "click" chemistry allowed the efficient functionalization of PVX with biotins, dyes, and PEGs. Fluorescent-labeled and PEGylated PVX particles revealed that different fluorescent labels have a profound effect on PVX-cell interactions. Applying bioconjugation chemistries to PVX opens the door for chemical functionalization with targeting and therapeutic molecules.
Medical subject headings
- Nanoparticles
- Nanotechnology
- Potexvirus