The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20018725.
- Also identified by DOI 10.1073/pnas.0909773106 and PMC identifier 2799747.
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Abstract
Translational control plays an important role in cell growth and tumorigenesis. Cap-dependent translation initiation of mammalian mRNAs with structured 5'UTRs requires the DExH-box protein, DHX29, in vitro. Here we show that DHX29 is important for translation in vivo. Down-regulation of DHX29 leads to impaired translation, resulting in disassembly of polysomes and accumulation of mRNA-free 80S monomers. DHX29 depletion also impedes cancer cell growth in culture and in xenografts. Thus, DHX29 is a bona fide translation initiation factor that potentially can be exploited as a target to inhibit cancer cell growth.
Medical subject headings
- Cell Proliferation
- Neoplasms
- Peptide Chain Initiation, Translational
- RNA Helicases