Multi-scale modelling in computational biomedicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 20028713.
- Also identified by DOI 10.1093/bib/bbp038.
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Abstract
The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-science systems, bridging a wide range of temporal and spatial scales. This article reviews the currently emerging field of multi-scale modelling in computational biomedicine. Many exciting multi-scale models exist or are under development. However, an underpinning multi-scale modelling methodology seems to be missing. We propose a direction that complements the classic dynamical systems approach and introduce two distinct case studies, transmission of resistance in human immunodeficiency virus spreading and in-stent restenosis in coronary artery disease.
Medical subject headings
- Computational Biology
- Models, Theoretical