Emerging roles of ATF2 and the dynamic AP1 network in cancer.
review · Level V
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- Record sourced from PubMed, PMID 20029425.
- Also identified by DOI 10.1038/nrc2681 and PMC identifier 2874064.
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Abstract
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.
Medical subject headings
- Activating Transcription Factor 2
- Gene Regulatory Networks
- Neoplasms
- Transcription Factor AP-1