Whole genome expression analysis reveals differential effects of TiO2 nanotubes on vascular cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20030358.
- Also identified by DOI 10.1021/nl903043z and PMC identifier 2833360.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The response of primary human endothelial (ECs) and vascular smooth muscle cells (VSMCs) to TiO2 nanotube arrays is studied through gene expression analysis. Microarrays revealed that nanotubes enhanced EC proliferation and motility, decreased VSMC proliferation, and decreased expression of molecules involved in inflammation and coagulation in both cell types. Networks generated from significantly affected genes suggest that cells may be sensing nanotopographical cues via pathways previously implicated in sensing shear stress.
Medical subject headings
- Endothelial Cells
- Genome
- Metal Nanoparticles
- Muscle, Smooth, Vascular
- Nanotubes
- Titanium