Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20037591.
- Also identified by DOI 10.1038/nmeth.1412 and PMC identifier 2849934.
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Abstract
Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.
Medical subject headings
- Behavior, Animal
- Biosensing Techniques
- Dopamine
- Electrochemistry
- Electrodes, Implanted
- Mesencephalon
- Monitoring, Ambulatory