Characterization of the human neutrophil alloantigen-3a.
basic_science · Level V
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- Record sourced from PubMed, PMID 20037594.
- Also identified by DOI 10.1038/nm.2070.
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Abstract
Transfusion-related acute lung injury (TRALI) is a frequent cause of transfusion-associated morbidity and mortality. Severe TRALI is often due to antibodies in blood components directed against the human neutrophil alloantigen-3a (HNA-3a). We show here that the HNA-3a antigen arises from a nucleotide polymorphism in the choline transporter-like protein-2 gene (SLC44A2), with the resulting variation at amino acid position 154 determining the reactivity of the protein with HNA-3a-specific antibodies; the variant with an arginine at this position, rather than a glutamine, constitutes the HNA-3a antigen. The molecular identification of this antigen should facilitate the development of assays for blood donor screening to lower the risk of TRALI.
Medical subject headings
- Acute Lung Injury
- Isoantigens
- Membrane Glycoproteins
- Membrane Transport Proteins
- Transfusion Reaction