Gd(III)-nanodiamond conjugates for MRI contrast enhancement.
basic_science · Level V
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- Record sourced from PubMed, PMID 20038088.
- Also identified by DOI 10.1021/nl903264h and PMC identifier 2829273.
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Abstract
A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T(1) of water protons with a per-Gd(III) relaxivity of 58.82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported.
Medical subject headings
- Contrast Media
- Gadolinium
- Magnetic Resonance Imaging
- Nanomedicine
- Nanostructures
- Nanotechnology