A case of seronegative HIV-1 infection.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20039801.
- Also identified by DOI 10.1086/649822 and PMC identifier 2821828.
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Abstract
Patients infected with human immunodeficiency virus type 1 (HIV-1) typically seroconvert within weeks of primary infection. In rare cases, patients do not develop antibodies against HIV-1 despite demonstrable infection. We describe here a human leukocyte antigen (HLA)-B*5802-positive individual who presented with acquired immune deficiency syndrome despite repeatedly negative HIV-1 antibody screening test results. Phylogenetic analysis of env clones revealed little sequence diversity, and weak HIV-1-specific CD8(+) T cell responses were present to Gag epitopes. The patient seroconverted after immune reconstitution during receipt of highly active antiretroviral therapy. Lack of an antibody response to HIV-1 is rare and appears to be due to a defect in HIV-1-specific immunity rather than infection with attenuated virus.
Medical subject headings
- HIV Antibodies
- HIV Infections
- HIV Seronegativity