Oct-3 is a maternal factor required for the first mouse embryonic division.
basic_science · Level V
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Abstract
Oct-3 is a POU domain transcription factor that binds the octamer DNA motif and is present in mouse oocytes before and after fertilization. When fertilized oocytes were injected with antisense Oct-3 oligonucleotides or double-stranded DNA containing the octamer motif, embryonic DNA synthesis was inhibited and the embryos were arrested at the one-cell stage. In vitro synthesized Oct-3 mRNA rescued the developmental block induced by antisense Oct-3 oligonucleotide. We conclude that maternally inherited Oct-3 is required for DNA replication and division of the one-cell embryo.
Medical subject headings
- Cleavage Stage, Ovum
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Oocytes
- Transcription Factors
- Zygote