Rapid sequencing of individual DNA molecules in graphene nanogaps.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20044842.
- Also identified by DOI 10.1021/nl9029237.
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Abstract
I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA's transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current-voltage characteristic is used to determine the base type independent of nanogap-width variations that cause the current to change by 5 orders of magnitude. The expected sequencing error rate is 0% up to a nanogap width of 1.6 nm.
Medical subject headings
- Carbon
- DNA
- Nanotechnology
- Sequence Analysis, DNA