Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 20047481.
- Also identified by DOI 10.1086/649874.
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Abstract
We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.
Medical subject headings
- Anti-HIV Agents
- Cerebrospinal Fluid
- Drug Resistance, Viral
- HIV Envelope Protein gp41
- HIV Infections
- HIV-1
- Peptide Fragments