Cu2+-labeled, SPION loaded porous silica nanoparticles for cell labeling and multifunctional imaging probes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20053440.
- Also identified by DOI 10.1016/j.biomaterials.2009.12.025.
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Abstract
We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell tracking with magnetic resonance (MR) imaging and positron emission tomography (PET). Herein we report the synthesis, surface functionalization and characterization of the magnetic nanoparticle-based probes and evaluate their cell-labeling efficacy, cytotoxicity and relaxivity in comparison to one of the most commonly utilized MRI contrast agents, Feridex.
Medical subject headings
- Adult Stem Cells
- Copper
- Ferrosoferric Oxide
- Molecular Imaging
- Molecular Probes
- Nanoparticles
- Silicon Dioxide