Integrins and mutant p53 on the road to metastasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20064366.
- Also identified by DOI 10.1016/j.cell.2009.12.016.
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Abstract
Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin alpha5beta1 and of epidermal growth factor receptor, promoting invasion and metastasis.
Medical subject headings
- Integrin alpha5beta1
- Neoplasm Metastasis
- Tumor Suppressor Protein p53