FANCD2 hurdles the DNA interstrand crosslink.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 20064367.
- Also identified by DOI 10.1016/j.cell.2009.12.006 and PMC identifier 2825892.
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Abstract
Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.
Medical subject headings
- DNA Repair
- Fanconi Anemia Complementation Group D2 Protein